ISIS Neutron and Muon Source Data Journal

SANS study of lipid-based nanocarriers as inhaled drug delivery systems for anti-tuberculosis chemotherapy

Abstract: The present project aims to achieve a more detailed structural characterization by SANS of Solid Lipid Nanoparticles (SLN) and liposomes in a perspective of an inhaled anti TB-therapy by means of DPI (dry powder inhaler) or MDI (metered dose inhaler) devices. This study will allow a deeper stuctural understanding of the placement/aggregation of rifampicin and isoniazid drugs into lipid vesicle carriers in order to reach a better knowledge of the encapsulation efficacy, stability into nanoparticles that strongly affects their antitubercular potentiality. These outcomes will be useful also for conceiving further co-loading experiments of two drugs in the same nanoparticle, which would allow a synergistic action after their local lung administration. Moreover, this analysis will provide us key information on the morphology of the lipid shell correlated to the loaded drug placement.

Principal Investigator: Professor Carlo Castellano
Experimenter: Dr Eliana Leo
Experimenter: Dr Sarah Rogers
Experimenter: Dr Fiorella Meneghetti
Experimenter: Professor Luca Costantino
Experimenter: Dr Fabio Domenici
Experimenter: Dr Valentina Iannuccelli

DOI: 10.5286/ISIS.E.RB1610099

ISIS Experiment Number: RB1610099

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Carlo Castellano et al; (2016): SANS study of lipid-based nanocarriers as inhaled drug delivery systems for anti-tuberculosis chemotherapy, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1610099

Data is released under the CC-BY-4.0 license.