ISIS Neutron and Muon Source Data Journal

NR Study of Selective Binding of a-Helix Antimicrobial Peptides onto Bacterial and Red Blood Cells Membrane Mimics Using Floating Bilayers

Abstract: In this work we will explore how to use PolRef to study the binding of our rationally designed peptide amphiphiles onto floating lipid bilayers mimicking G- bacterial and red blood cell membranes. To help gain insight into the selective binding processes, we will select 2 representative peptides at 2 concentrations (below and above their MICs to typical bacteria) under 3 contrasts (d- and h-lipids and H2O/D2O), requesting 6 days of PolRef beam time. This work will provide valuable molecular insight of peptide selectivity to different membranes under different conditions.

Principal Investigator: Professor Jian Lu
Experimenter: Mr Charles Smith
Experimenter: Miss Daniela Ciumac
Experimenter: Dr Luke Clifton
Experimenter: Dr Arwel Hughes
Local Contact: Dr Timothy Charlton
Experimenter: Dr Zongyi Li
Local Contact: Dr Christy Kinane

DOI: 10.5286/ISIS.E.RB1520333

ISIS Experiment Number: RB1520333

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Jian Lu et al; (2016): NR Study of Selective Binding of a-Helix Antimicrobial Peptides onto Bacterial and Red Blood Cells Membrane Mimics Using Floating Bilayers, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1520333

Data is released under the CC-BY-4.0 license.