ISIS Neutron and Muon Source Data Journal

Cell-penetrating peptides interaction with model membranes

Abstract: Cell-penetrating peptides (CPPs) are short cationic peptides that are efficiently taken up by cells. They are able to co-internalize therapeutic molecules into cells for intracellular targets. With the increasing need for efficient carrier systems, CPPs have the potential to become an important tool to deliver therapeutic molecules across membranes. The mechanism of cell entry for the CPPs is not well understood, but the initial membrane interaction is a crucial factor for the internalization process. NR data will give a unique insight on how CPPs interact with the cell membrane and even discern the effect of fluorophore labeling on CPPs-membrane interactions. This knowledge can be of great value in the development of optimized CPPs carriers suitable for use in drug delivery systems and in understanding the consequences of using fluorophores in drug delivery efficacy assessment.

Principal Investigator: Professor Marité Cárdenas Gómez
Local Contact: Dr Maxmilian Skoda
Experimenter: Dr Tania Lind
Experimenter: Dr Kathryn Browning
Experimenter: Miss Sofie Hedegaard
Experimenter: Dr Selma Maric
Local Contact: Dr Mario Campana
Experimenter: Mr Simon Isaksson

DOI: 10.5286/ISIS.E.RB1520082

ISIS Experiment Number: RB1520082

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Marité Cárdenas Gómez et al; (2016): Cell-penetrating peptides interaction with model membranes, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1520082

Data is released under the CC-BY-4.0 license.