ISIS Neutron and Muon Source Data Journal

Investigation on the structural properties of doxorubicin-loaded PEGylated liposomes (Doxil®)

Abstract: Doxil® is a marketed liposomal formulation containing the anticancer drug doxorubicin. Recently, SAXS measurements have evidenced a crystalline fibrillar structure for the encapsulated doxorubicin at 25°C. We have already performed a characterization of the thermal behaviour of the formulation by microcalorimetry, and high-resolution ultrasonic spectroscopy in order to investigate better the phase transition of the liposomal membrane and of the encapsulated drug. We propose here to perform SANS measurements on Doxil® and unloaded liposomes for comparison at four selected temperatures. As previously verified by preliminary spectra at 20°C, this technique, thanks to H2O/D2O sub-phase matching, is able to discriminate between the contribution of the phospholipidic components and drug nanocrystals. Thus, it represents a valid tool for the characterization of the thermal behaviour of Doxil®.

Principal Investigator: Dr Diego Romano Perinelli
Experimenter: Dr Mario Campana
Local Contact: Dr James Doutch
Experimenter: Professor Luca Casettari

DOI: 10.5286/ISIS.E.RB1720312

ISIS Experiment Number: RB1720312

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Diego Romano Perinelli et al; (2017): Investigation on the structural properties of doxorubicin-loaded PEGylated liposomes (Doxil®) , STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1720312

Data is released under the CC-BY-4.0 license.