ISIS Neutron and Muon Source Data Journal

The interaction of novel gold supraparticles with model lipid membranes

Abstract: Engineered nanoparticles (NPs) found large application in medicine as theranostic materials for the diagnosis and therapy of many diseases. The understanding of the interactions of NPs with cell membranes is of fundamental importance both to tune the efficiency of NPs entry in the cell and limit their cytotoxicity. Neutron reflectometry (NR) is a powerful technique widely used to examine model membranes morphology and their response to different effectors. We propose the use of this tool to understand the nature of the interaction between novel gold NPs and a model membrane whihc consists in a tether lipi bilayer, in vitro and in a relevant biological environment when NPs are in contact with proteins and form a new biological entity called protein corona NPs (PC).

Principal Investigator: Dr Francesca Baldelli Bombelli
Local Contact: Dr Nina-Juliane Steinke
Experimenter: Dr Marco Maccarini
Experimenter: Dr Giovanna Fragneto
Experimenter: Mr Loic Joly

DOI: 10.5286/ISIS.E.RB1720380

ISIS Experiment Number: RB1720380

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Francesca Baldelli Bombelli et al; (2017): The interaction of novel gold supraparticles with model lipid membranes, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1720380

Data is released under the CC-BY-4.0 license.