ISIS Neutron and Muon Source Data Journal

Structure of antibiotic mixtures in lung surfactant membrane models at the air-water interface

Abstract: Clarithromycin and Levofloxacin are essential antibiotics used to treat bacterial infections such as tuberculosis and pneumonia. Lung surfactants may be used as drug carrier of antibiotics directly into the airways. The phospholipid DPPC is a major lipid in commercial lung surfactants and is used to mimic their surface and mechanical properties so that it is a reasonable model. This proposal intends to investigate the structure of DPPC-antibiotics mixed monolayers in order to understand if they are suitable to be used as drug delivery systems in respiratory medicine. The idea is to use neutron reflectometry (NR) to characterize the density, packing, thickness, surface activity, and molecular area of the film at the air-water interface. Also, NR is a suitable technique for the study of interfacial structure, molecular organization and composition of mixed films.

Principal Investigator: Professor Karen Edler
Experimenter: Miss Stephanie Ortiz
Experimenter: Dr Andre Pimentel
Local Contact: Dr Mario Campana
Experimenter: Dr Marcelo da Silva
Experimenter: Dr Naomi Elstone

DOI: 10.5286/ISIS.E.RB1710178

ISIS Experiment Number: RB1710178

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Karen Edler et al; (2017): Structure of antibiotic mixtures in lung surfactant membrane models at the air-water interface, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1710178

Data is released under the CC-BY-4.0 license.