ISIS Neutron and Muon Source Data Journal

The Effect of Framework Structure and Composition on Controlled Drug Release by Zeolites

Abstract: The mobility of beta-blocker and angina/hypertension drug atenolol in zeolites FAU and BEA will be probed using QENS to understand the importance of fundamental sorbate-framework interactions on the controlled release of these promising new dosage forms. Subtle changes to the framework composition have significant effects on the measured release rates of the drug. We will measure the atenolol mobility in FAU with Si/Al ratios of 5 and 80, where (counterintuitively) the release rate is significantly higher in the former despite there being more Bronsted sites for favourable interactions (not emulated by MD simulations of mobility). We will also measure the mobility in smaller pore BEA in comparison with FAU, where simulations show slower mobility in the former correlating with the release rate. We may then gauge the importance of fundamental mobility on controlled drug release rates.

Principal Investigator: Dr Paul Cox
Experimenter: Dr Alexander O'Malley
Local Contact: Dr Ian Silverwood
Experimenter: Professor Richard Catlow

DOI: 10.5286/ISIS.E.RB1710135

ISIS Experiment Number: RB1710135

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Paul Cox et al; (2017): The Effect of Framework Structure and Composition on Controlled Drug Release by Zeolites, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1710135

Data is released under the CC-BY-4.0 license.