ISIS Neutron and Muon Source Data Journal

Solubilisation in Zwitterionic Micelles: Effect of Structure

Abstract: The project aims to probe the relationship between surfactant structure, the micelles formed in solution, and the type of drug molecules that the micelles solubilise. Once obtained this understanding should allow the rational design of novel surfactant molecules to form micelles in which the drug loading is optimized. In the present study a series of structurally related steroidal drug molecules, differing only in the extent of their polarity, namely 4-cholesten-3-one and adrenosterone will be solubilised in 3 types of zwitterionic micelles formed by C12 tailed surfactants. The results of the study will be complemented by molecular dynamic simulations of the drug in the surfactant micelles using the aggregation number obtained from SANS. The results of the study are essential to aiding the rational design and selection of surfactant micelles to optimise drug solubilisation.

Principal Investigator: Professor Jayne Lawrence
Local Contact: Dr Najet Mahmoudi
Experimenter: Mr Xing Chen
Experimenter: Dr Delaram Ahmadi
Experimenter: Dr Peixun Li
Local Contact: Dr James Doutch
Experimenter: Miss yanan shao

DOI: 10.5286/ISIS.E.RB1620386

ISIS Experiment Number: RB1620386

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
Select the data format above to find out more about it.

Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Jayne Lawrence et al; (2016): Solubilisation in Zwitterionic Micelles: Effect of Structure, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1620386

Data is released under the CC-BY-4.0 license.