ISIS Neutron and Muon Source Data Journal

Feasibility studies of neutron protein crystallography at ISIS using perdeuterated rubredoxin

Abstract: We propose to use instruments SXD and WISH to carry out a detailed feasibility study of neutron protein crystallography at ISIS. Since one of the major impediments to protein crystallography with neutrons is hydrogen incoherent scattering, we will focus on small protein systems that are perdeuterated. The overall aim of the the study will be to identify the optimal beam conditioning (wavelength spread and brilliance) and timeslicing for small proteins and to develop an understanding of the demands necessary for larger protein systems where time-of-flight instruments could provide significant advantages.

Principal Investigator: Professor Trevor Forsyth
Local Contact: Dr Fabio Orlandi
Experimenter: Dr Matthew Blakeley
Experimenter: Dr Maxime Cuypers
Experimenter: Dr Nicolas Coquelle
Experimenter: Dr Estelle Mossou
Experimenter: Dr Michael Haertlein
Experimenter: Dr Silvia Capelli
Experimenter: Dr Sax Mason
Experimenter: Dr Juliette Devos
Experimenter: Mr Ashley Jordan

DOI: 10.5286/ISIS.E.RB1710506

ISIS Experiment Number: RB1710506

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Trevor Forsyth et al; (2017): Feasibility studies of neutron protein crystallography at ISIS using perdeuterated rubredoxin, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1710506

Data is released under the CC-BY-4.0 license.