ISIS Neutron and Muon Source Data Journal

Lysozyme Functionalised Titania: A Kinetic & Structural Optimisation

Abstract: Hospital-acquired infections of medical devices result in approximately 100,000 deaths each year in the US alone, it is therefore a priority to tackle this. To this end, we have developed an method of functionalising titania surfaces with lysozyme, an enzyme which breaks down the cell walls of bacteria. This approach shows great promise for killing bacteria when compared to native titania surfaces, but any further improvement requires an in-depth understanding of the structure of the surfaces. In particular, it's known that the mechanism of lysozyme adsorption to the surfaces plays an important role. Therefore, within the scope of this study we propose to use reflectometry to understand the structural parameters of each step in the functionalisation process, followed by an in-depth kinetic study of the adsorption process to complement ongoing gravimetric studies.

Principal Investigator: Dr Gavin Hazell
Local Contact: Dr Rebecca Welbourn
Experimenter: Dr Rob Barker

DOI: 10.5286/ISIS.E.RB1710422

ISIS Experiment Number: RB1710422

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Gavin Hazell et al; (2017): Lysozyme Functionalised Titania: A Kinetic & Structural Optimisation, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1710422

Data is released under the CC-BY-4.0 license.