ISIS Neutron and Muon Source Data Journal

PROBING DRUG PHARMACODYNAMICS BY QENS: THE EFFECT OF CISPLATIN-LIKE ANTICANCER DRUGS ON DNA DYNAMICAL PROFILE

Abstract: Water supports vital biochemical processes in living organisms, namely through maintenance of the three-dimensional architecture of biopolymers by a tight interplay with their hydration shells. Hence, any mobility changes within this hydration layer may affect the biopolymer´s conformational and dynamical profile, which rule biofunctionality.Building on the success of a previous experiment on human cells (RB1510054, paper under review [1,2]), the present study aims to apply QENS (with isotope labelling) for probing the effect of cisplatin-like anticancer drugs on the dynamical behaviour of DNA, through the impact on its hydration layer. This is a timely and innovative way of tackling a drug´s pharmacodynamics at a molecular level, that should provide data allowing a thorough understanding of the drug´s mode of action, water being suggested as a secondary pharmacological target.

Principal Investigator: Dr Maria Paula Marques
Experimenter: Dr Ana Batista de Carvalho
Experimenter: Dr Luis Alberto Batista de Carvalho
Experimenter: Dr Victoria Garcia Sakai

DOI: 10.5286/ISIS.E.RB1710167

ISIS Experiment Number: RB1710167

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Maria Paula Marques et al; (2017): PROBING DRUG PHARMACODYNAMICS BY QENS: THE EFFECT OF CISPLATIN-LIKE ANTICANCER DRUGS ON DNA DYNAMICAL PROFILE, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1710167