ISIS Neutron and Muon Source Data Journal

Increasing Drug Solubilisation: Matching Drug Structure with Surfactant Hydrophobe

Abstract: It is estimated that > 40% of new drug molecules are poorly water soluble. Although there are many options for improving aqueous solubility, few if any, achieve the required level of solubility. For many reasons, solubilisation in nonionic surfactant micelles is a favoured means of increasing apparent aqueous solubility. Recently our group has found that significant increases in drug solubilisation can be achieved by ‘matching' the hydrophobe of the surfactant to the drug structure. In particular, we found that the drug, ibuprofen, is solubilised extremely well in micelles formed by the nonionic surfactant, Triton X-100, which has a hydrophobe which closely matches the structure of ibuprofen. The aim of the proposed SANS study is to understand the nature of the incorporation of the drug ibuprofen into Triton X-100 micelles in order to aid our rational design of new, improved surfactants.

Principal Investigator: Professor Jayne Lawrence
Experimenter: Dr Dave Barlow
Local Contact: Dr Sarah Rogers
Experimenter: Miss Simona-Vyara Kolarova
Experimenter: Mr Xing Chen
Experimenter: Miss yanan shao

DOI: 10.5286/ISIS.E.RB1620385

ISIS Experiment Number: RB1620385

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Jayne Lawrence et al; (2017): Increasing Drug Solubilisation: Matching Drug Structure with Surfactant Hydrophobe , STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1620385

Data is released under the CC-BY-4.0 license.