ISIS Neutron and Muon Source Data Journal

Comparing peptide folding states in non-aqueous and aqueous solutions

Abstract: How proteins fold from their linear sequence into their functional structures is still not understood and the misfolding of proteins is linked to a variety of diseases - such as Alzheimer's, Huntington's and diabetes. In life, proteins fold in aqueous solution and as such investigation of this process must be assessed in a similar environment. This proposal is part of a programme of work to investigate protein folding in solution using small peptides which adopt a range of conformations in solution. This allows for an assessment of hydration in the folded and unfolded states of a peptide allowing for important details of how hydration contributes to this process to be determined.

Principal Investigator: Dr Sylvia McLain
Local Contact: Dr Sam Callear [Deactivated]
Experimenter: Mr Thomas Dixon
Experimenter: Ms Nicola Steinke
Local Contact: Dr Silvia Imberti

DOI: 10.5286/ISIS.E.RB1710012

ISIS Experiment Number: RB1710012

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
Select the data format above to find out more about it.

Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Sylvia McLain et al; (2017): Comparing peptide folding states in non-aqueous and aqueous solutions, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1710012

Data is released under the CC-BY-4.0 license.