ISIS Neutron and Muon Source Data Journal

Assembling Biomimetic layers on monolayers of Gold Nanoparticles

Abstract: Gold provides a high quality surface on which to arrange biomolecules such as proteins since we can use cysteine amino acids to deliver gold thiol chemical bonds which can orient the proteins in a defined manner. Whilst a thin layer of gold can be produced by sputtering this is opaque and limits the use of these surfaces in microscopy which is a major component of biological analysis. In collaboration with Orla Protein Technologies Ltd we are studying glass slides upon which a layer of gold nanoparticles has been assembled. Biomolecules can be assembled on these layers which are being measured by a range of technique including electron microscopy, XPS and AFM but only neutron reflectivity can image and provide a profile of the density and distribution of all the components. We hope to use neutron reflectivity in conjunction with QCM-D which can measure the mass increases directly.

Principal Investigator: Professor Jeremy Lakey [Deactivated] [Deactivated]
Experimenter: Dr Maxmilian Skoda
Experimenter: Mr Timothy Robson
Experimenter: Dr Nicolò Paracini
Local Contact: Dr Luke Clifton

DOI: 10.5286/ISIS.E.RB1520380

ISIS Experiment Number: RB1520380

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Jeremy Lakey [Deactivated] [Deactivated] et al; (2016): Assembling Biomimetic layers on monolayers of Gold Nanoparticles, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1520380

Data is released under the CC-BY-4.0 license.