ISIS Neutron and Muon Source Data Journal

INTRACELLULAR WATER AS A SECONDARY DRUG TARGET IN CHEMOTHERAPY: THE IMPACT OF A NEW Pd-BASED ANTICANCER AGENT ON HUMAN BREAST CANCER CELLS

Abstract: Water plays a vital role in biochemical processes in a living organism. Within a cell, intracellular water structure/dynamics are known to be changed by metabolites or extrinsic entities (e.g. drugs), while water properties are prone to affect the function of biomolecules and hence cell viability. Intracellular water may thus be a potential secondary drug target. This is an innovative way for tackling the drug´s pharmacodynamics aiming at an enhanced therapeutic activity.This study aims at exploring this concept for a Pd(II) anticancer agent, following a similar experiment on cisplatin that yielded promising results (OSIRIS/RB1400034 and 1510054). Building on this successful proof-of-concept study, the QENS technique (with isotope labelling) will be used to probe the effect of a Pd(II) anticancer agent on water dynamics in low prognostic triple-negative human breast cancer cells.

Principal Investigator: Dr Maria Paula Marques
Experimenter: Mrs Louise Hatter
Experimenter: Dr Victoria Garcia Sakai
Experimenter: Professor Luis Alberto Batista de Carvalho
Experimenter: Dr Ana Batista de Carvalho

DOI: 10.5286/ISIS.E.RB1620050

ISIS Experiment Number: RB1620050

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
Select the data format above to find out more about it.

Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Maria Paula Marques et al; (2017): INTRACELLULAR WATER AS A SECONDARY DRUG TARGET IN CHEMOTHERAPY: THE IMPACT OF A NEW Pd-BASED ANTICANCER AGENT ON HUMAN BREAST CANCER CELLS, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1620050