ISIS Neutron and Muon Source Data Journal

A comparative NR study of interaction of short designed antimicrobial peptides to accurate gram negative and red blood cells model membranes

Abstract: The global increase of bacterial resistance to antibiotics has led to increasing interest in research focusing on the development and characterization of new antimicrobial agents. One class of promising antimicrobials found in nature are Antimicrobial Peptides (AMP’s) [1]. In contrast to most existing therapeutic antimicrobials, and so it is thought that resistance would be far more difficult to develop to AMP’s. We have designed a novel class of AMP's with the general sequence G(IIKK)nI-NH2, with n-the number of coils of α-helix (n=2-4). In a recent experiment we have studies the interaction of these peptides with floating bilayers intended to mimic gram negtive of eukaryotic membranes, and obesrved changes to membrane structure on binding. In this experiment we wish to extend this preliminary work by studying the concentration dependence of peptide interaction with membranes.

Principal Investigator: Dr Arwel Hughes
Local Contact: Dr Andrew Caruana
Experimenter: Mr Haoning Gong
Experimenter: Mr Charles Smith
Experimenter: Dr Luke Clifton
Experimenter: Miss Daniela Ciumac
Experimenter: Professor Jian Lu

DOI: 10.5286/ISIS.E.RB1620474

ISIS Experiment Number: RB1620474

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
Select the data format above to find out more about it.

Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Arwel Hughes et al; (2016): A comparative NR study of interaction of short designed antimicrobial peptides to accurate gram negative and red blood cells model membranes, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1620474

Data is released under the CC-BY-4.0 license.