ISIS Neutron and Muon Source Data Journal

Membrane-stacking properties of myelin proteins

Abstract: Myelin is the multilamellar structure that ensheaths axons and accelerates nervous impulses in the nervous system. The fine structure of myelin remains to be further characterized on the biomolecular scale. There are many myelin proteins that contribute to myelin membrane stacking and are involved in demyelinating diseases. We propose an experiment at the INTER neutron reflectometer, where the properties of these proteins can be investigated on supported stacked lipid bilayers. The proteins and their properties have already been characterized in biomimetic systems at SURF, ISIS and D17, ILL, and now we wish to continue this at INTER. This helps us understand the ultrastructure of myelin from a structural and functional aspect. In this proposal we ask for 6 days of beamtime to carry out measurements involving three abundant myelin proteins in various lipid environments and contrasts.

Principal Investigator: Dr Petri Kursula
Local Contact: Dr Maxmilian Skoda
Experimenter: Dr Anne Baumann
Experimenter: Dr Arne Raasakka
Local Contact: Dr Rebecca Welbourn
Experimenter: Dr Rob Barker
Experimenter: Miss Samantha Ryan

DOI: 10.5286/ISIS.E.RB1620422

ISIS Experiment Number: RB1620422

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Petri Kursula et al; (2017): Membrane-stacking properties of myelin proteins, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1620422

Data is released under the CC-BY-4.0 license.