ISIS Neutron and Muon Source Data Journal

Effect of polar solvent on the structure of monolayers of phospholipid

Abstract: It is the aim of the proposal is to perform neutron reflectivity (NR) studies combined with contrast variation to determine the structure of phospholipid monolayers on a non-polar solvent (namely a diol either 1,2 propanediol (propylene glycol), 1,3 propanediol, 1,2 butanediol or 1,4 butanediol or a triol 1,2,3 propanediol (glycerol)) at the air-solvent interface. Of particular interest is the effect of the structure of the solvent on the formation of monolayers of the phospholipid, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC). The information gained from these studies (e.g. are per molecule and lipid thickness) will aid the understanding of the structures this lipid, POPC, forms in the non-aqueous polar solvents and will inform the future development of these interesting and potentially important delivery systems.

Principal Investigator: Professor Jayne Lawrence
Experimenter: Mr Xing Chen
Experimenter: Miss yanan shao
Experimenter: Dr Dave Barlow
Experimenter: Miss Simona-Vyara Kolarova
Experimenter: Professor Gino Martini
Local Contact: Dr Maxmilian Skoda

DOI: 10.5286/ISIS.E.RB1620384

ISIS Experiment Number: RB1620384

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Jayne Lawrence et al; (2017): Effect of polar solvent on the structure of monolayers of phospholipid, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1620384

Data is released under the CC-BY-4.0 license.