ISIS Neutron and Muon Source Data Journal

Exploring the interactions between vesicles/viruses and supported lipid bilayers using neutron reflectometry

Abstract: Many biological processes occur at the interface of cells, at the so called cell membrane, such as internalization of biological nanoparticles, including virions, exosomes and nanoparticle-based drug-delivery vehicles. In this project, we plan to use neutron reflectometry (NR) to measure the distances between a supported cell-membrane mimic and different models of lipid-based biological nanoparticles. In this way, we will assess how the distance between these entities is influenced by external components, e.g. charge and ligand-receptor density, to thereby gain new knowledge on how e.g. binding-induced nanoparticle deformation and membrane fusion are controlled by inter-membrane distance. This project should be the first of its kind to address such questions using NR, and will contribute improved determination of inter-membrane distances in biologically important processes.

Principal Investigator: Professor Fredrik Höök
Experimenter: Dr Hudson Pace
Local Contact: Dr Rebecca Welbourn
Experimenter: Dr Antonius Armanious
Experimenter: Dr Yuri Gerelli
Experimenter: Dr Emanuel Schneck
Experimenter: Dr Samantha Micciulla
Experimenter: Dr Bjorn Agnarsson

DOI: 10.5286/ISIS.E.RB1710273

ISIS Experiment Number: RB1710273

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Fredrik Höök et al; (2017): Exploring the interactions between vesicles/viruses and supported lipid bilayers using neutron reflectometry, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1710273

Data is released under the CC-BY-4.0 license.