ISIS Neutron and Muon Source Data Journal

Sequential adsorption of atherosclerotic lipoproteins to study the protective role of high density lipoproteins

Abstract: Atherosclerosis is a major contributor to global morbidity and mortality with 31 % of all deaths in 2008 linked to cardiovascular disease. The development of the disease has been linked to the cholesterol transport system. Uptake, transport and deposition of atherogenic cholesterol esters and triglycerides is facilitated by lipoprotein particles in the blood stream. High (HDL) and low (LDL) density lipoproteins are aggregates of lipophilic cholesterol esters and triglycerides encapsulated by a lipid monolayer and apolipoproteins. HDL has been shown to have a protective effect on the body. In this work we aim to study the effect of pre-coating lipid bilayers with atheroprotective HDL lipoprotein particles on LDL exchange mechanisms using neutron reflection which is especially sensitive to the adsorption, exchange and uptake of lipids from bilayers.

Principal Investigator: Professor Martin Malmsten
Local Contact: Dr Maxmilian Skoda
Experimenter: Miss Josefine Eilsø Nielsen
Experimenter: Miss Sarah Waldie
Experimenter: Dr Tania Lind
Local Contact: Dr Nina-Juliane Steinke
Experimenter: Professor Marité Cárdenas Gómez
Experimenter: Dr Kathryn Browning

DOI: 10.5286/ISIS.E.RB1710093

ISIS Experiment Number: RB1710093

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Martin Malmsten et al; (2017): Sequential adsorption of atherosclerotic lipoproteins to study the protective role of high density lipoproteins, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1710093

Data is released under the CC-BY-4.0 license.