ISIS Neutron and Muon Source Data Journal

Deep Eutectic Solvents in Chemical Synthesis: Probing Solvent-Substrate Interactions

Abstract: Volatile organic solvents are used in the majority of chemical syntheses but due to their adverse effects on health and the environment, replacements are sought. Recent work on deep eutectic solvents (DES) has demonstrated that these novel liquids can replace organic solvents and bring exciting advantages. In addition to being inexpensive, non-flammable and having a low volatility it has been shown that reactions using organolithium reagents in DES can be carried out at room temperature in air, in the presence of water - conditions that are normally incompatible with polar organometallic compounds. Reactions in DES also had improved yields and better selectivities than standard inert atmosphere protocols. Here we wish to probe DES-substrate and DES-product interactions for a model ketone used in an arylation reaction with phenyl-lithium to understand how DES promote these reactions.

Principal Investigator: Professor Karen Edler
Local Contact: Dr Tom Headen
Experimenter: Ms Ria Atri
Experimenter: Dr Daniel Bowron
Experimenter: Professor Eva Hevia
Experimenter: Professor John Holbrey
Experimenter: Mr Jake Hooton
Experimenter: Dr Oliver Hammond

DOI: 10.5286/ISIS.E.RB1820315

ISIS Experiment Number: RB1820315

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Karen Edler et al; (2018): Deep Eutectic Solvents in Chemical Synthesis: Probing Solvent-Substrate Interactions, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1820315

Data is released under the CC-BY-4.0 license.