ISIS Neutron and Muon Source Data Journal

Impact of homo- and hetero-association of complex molecular nano-sized drug delivery systems

Abstract: The present proposal concerns a PEGylated, hydrophobic drug containing polylysine dendrimer that demonstrates unexplained batch-to-batch variability in that two batches of the AZD0466 drug-dendrimer conjugate exhibit slightly different particle sizes and in vivo behaviour, whereas drug loading and drug release is similar for both batches. SANS in combination with contrast variation will be used to determine how the molecular architecture of the dendrimer molecules alters in the presence of drug and by changing solvent (from water to methanol). The information obtained in the present study will be invaluable in understanding how these dendrimer nanoparticles can be successfully exploited as drug delivery vehicles.

Principal Investigator: Professor Jayne Lawrence
Experimenter: Mr Weimin Li
Local Contact: Dr Najet Mahmoudi
Experimenter: Dr Kevin Treacher
Experimenter: Dr Mark Jackman

DOI: 10.5286/ISIS.E.RB1820524

ISIS Experiment Number: RB1820524

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Jayne Lawrence et al; (2018): Impact of homo- and hetero-association of complex molecular nano-sized drug delivery systems, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1820524

Data is released under the CC-BY-4.0 license.