ISIS Neutron and Muon Source Data Journal

Neutron Reflection Studies on Adsorption of Lauroyl-L-Carnitine (C12-L-Canitine) at the SiO2/water Interface

Abstract: Acyl L-Carnitines are a group of novel surfactants with attractive physical and biological properties associated with their head group charge features. This work proposes to use neutron reflection as the unique technique to determine the thickness and composition of surfactant adsorbed layers at the solid/water interface. Because silica is the model substrate that has been widely used for studying protein adsorption, it has been chosen here, also due to its mimicry to glass widely used as containers for therapeutic proteins. Because the head group has special charge responses to pH, it will be of interest to examine how the adsorbed layer structure changes with pH and ionic strength. We request 3 days of Inter (or 4 days of Surf) beam time to complete the proposed measurements.

Principal Investigator: Professor Jian Lu
Experimenter: Mr Ruiheng Li
Local Contact: Dr Maxmilian Skoda
Experimenter: Mr Huayang Liu
Experimenter: Dr Peixun Li
Experimenter: Mr Haoning Gong
Experimenter: Dr Zongyi Li
Experimenter: Dr Xuzhi Hu
Experimenter: Mr KE FA

DOI: 10.5286/ISIS.E.RB1820135

ISIS Experiment Number: RB1820135

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Jian Lu et al; (2018): Neutron Reflection Studies on Adsorption of Lauroyl-L-Carnitine (C12-L-Canitine) at the SiO2/water Interface , STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1820135

Data is released under the CC-BY-4.0 license.