ISIS Neutron and Muon Source Data Journal

Interactions of lipidic cubic nanoparticles with model lipid biomembranes at the air water interface

Abstract: Lipidic cubic nanoparticles (LCNPs) have been extensively studied as therapeutic agents and delivery systems due to their biocompatibility, ease of drug encapsulation and targeting. Better understanding of the interplay between LCNPs and model lipid membranes is needed in order to exploit their use in clinical applications. We have shown that less condensed layers facilitate incorporation of the LCNPs material while highly organized layers keep the LCNPs intact and outside the monolayer, but specific information about the structure and composition of the system is missing. We propose to characterize the interactions of LCNPs at 2 surface pressures and with 2 different lipid monolayers (acting as simplified models of healthy and cancer cell membranes) using neutron reflectivity. Information about lipid exchange and particle attachment will pave the way for future drug release studies.

Principal Investigator: Dr Richard Campbell
Experimenter: Dr Imre Varga
Experimenter: Professor Jayne Lawrence
Local Contact: Dr Maxmilian Skoda
Experimenter: Mr ANDREA TUMMINO
Experimenter: Dr Dorota Matyszewska
Experimenter: Dr Mario Campana
Experimenter: Dr Ewa Nazaruk

DOI: 10.5286/ISIS.E.RB1820288

ISIS Experiment Number: RB1820288

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Richard Campbell et al; (2018): Interactions of lipidic cubic nanoparticles with model lipid biomembranes at the air water interface, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1820288

Data is released under the CC-BY-4.0 license.