ISIS Neutron and Muon Source Data Journal

Contrast variation SANS to understand drug directed assembly of multi lamellar liposomes

Abstract: Recurring infection following dental interventions such as fillings is the most common reason for failure, leading to further treatments including root canal therapy, where the infected dental pulp and root tissue is removed and replaced with an inert substance such as dental cement. Over half of root canal treatments still fail due to re-infection, leading to yet further treatment to remove the tooth. To address this problem, we have developed a series of antimicrobial liposomes, and seek to use neutron scattering to understand how incorporation of the drug affects the structure of the liposomes. We hope this will help to explain the differences in efficacy we have seen during our formulation development work, and accellerate progress in developoing formulations with different anytimicrobial drugs.

Principal Investigator: Dr Alison Paul
Experimenter: Professor Alastair Sloan
Experimenter: Dr Elen Everett
Local Contact: Dr Steve King
Experimenter: Dr Craig James
Experimenter: Professor Rachel Errington

DOI: 10.5286/ISIS.E.RB1820359

ISIS Experiment Number: RB1820359

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Alison Paul et al; (2018): Contrast variation SANS to understand drug directed assembly of multi lamellar liposomes, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1820359

Data is released under the CC-BY-4.0 license.