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Substrate-dependent structure of thin hydrogel films
Abstract: Hydrogels are water-rich polymer networks made from natural or synthetic polymers, which are widely used in biomaterials, medicine and antifouling. We have developed PEG-based hydrogels which are grafted through UV-initiated free-radical polymerization, suitable for use in biosensing applications since they have low non-specific protein adsorption and permit controlled modification by ligands. The processing can be tuned to produce a given polymer mass per surface area, but growth rates vary between substrate types, and is 2-4 times faster on gold than on silicon; two substrate types which are important for biosensors. We will investigate how this affects the structure of the swollen hydrogels. The low polymer/water contrast in the wet polymer makes structural characterization difficult, but via H-D-substitution, neutron reflectometry can be used to determine the swelling and density.
Principal Investigator: Dr Thomas Ederth
Local Contact: Dr Jos Cooper
Experimenter: Dr Bela Nagy
DOI: 10.5286/ISIS.E.RB1820546
ISIS Experiment Number: RB1820546
Part DOI | Instrument | Public release date | Download Link |
---|---|---|---|
10.5286/ISIS.E.99691448 | OFFSPEC | 10 February 2022 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Dr Thomas Ederth et al; (2018): Substrate-dependent structure of thin hydrogel films, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1820546
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