ISIS Neutron and Muon Source Data Journal

Rhamnolipids and Amphotericin B: a potential highly specific delivery system for treatment of systemic fungal infections.

Abstract: Rhamnolipids are a type of glycolipid biosurfactant, produced as secondary metabolites by various Pseudomonas and Burkholderia species; they have been shown to possess anti-bacterial and anti-fungal activity. They can now be produced with high efficiency allowing for more economical production and industrial scalability. Numerous studies have reviewed the potential applications of biosurfactants that are useful for therapeutic applications that include cancer therapeutics and drug delivery systems. Their low toxicity, surface activity, and anti-mycotic properties (8) make them promising candidates for development of active delivery systems for anti-fungal drugs like amphotericin B (AmB). In the studies proposed here, our aim is to carry out small angle neutron scattering (SANS) experiments to determine the structure and stability of vesicles prepared from R1(/sterol) with and without AmB

Principal Investigator: Dr Fabrizia Foglia
Local Contact: Dr Adam Washington
Experimenter: Dr Dave Barlow
Experimenter: Professor Jayne Lawrence
Experimenter: Mr Xing Chen
Experimenter: Dr Farooq Malik
Experimenter: Dr Delaram Ahmadi

DOI: 10.5286/ISIS.E.RB1820456

ISIS Experiment Number: RB1820456

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
Select the data format above to find out more about it.

Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Fabrizia Foglia et al; (2018): Rhamnolipids and Amphotericin B: a potential highly specific delivery system for treatment of systemic fungal infections., STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1820456

Data is released under the CC-BY-4.0 license.