ISIS Neutron and Muon Source Data Journal

Self-assembled thermoresponsive fluoropolymer nanostructures for MRI tumour imaging

Abstract: Nanoparticles made of polymers containing fluorine have promising applications since magnetic resonance imaging using fluorinated contrast agents (19F MRI) enables enhanced resolution and selectivity due to the negligible fluorine background in living tissues. We prepared several types of fluorinated diblock copolymers for this purpose A critical parameter is the density of 19F atoms in the core of the micelles, which has to be relatively high to ensure sufficient imaging contrast. To evaluate this density, the radius of the core and the aggregation number Ng of the micelles needs to be known to determine the number of fluorinated blocks in the core. The degree of hydration of the core related to the density also influences magnetic relaxivity of the fluorine atoms in it. SANS will be used to determine Ng and the core radius of micelles using contrast matching of the shell.

Principal Investigator: Dr Petr Stepanek
Experimenter: Miss Kristyna Kolouchova
Experimenter: Mr David Babuka
Local Contact: Dr Steve King

DOI: 10.5286/ISIS.E.RB1820224

ISIS Experiment Number: RB1820224

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Petr Stepanek et al; (2018): Self-assembled thermoresponsive fluoropolymer nanostructures for MRI tumour imaging, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1820224

Data is released under the CC-BY-4.0 license.