ISIS Neutron and Muon Source Data Journal

Structure and gelation of poloxamer based hydrogels for injectable drug delivery

Abstract: We seek to develop hydrogel formulations for injectable controlled drug delivery from Pluronics to enhance patient compliance, decrease side effects and reduce dose and frequency. Pharmaceutically, these systems are attractive due to their unique sol-gel phase transition in the body, biocompatibility and safety and are injected as solutions before transforming to gel matrices at body temperature. Pluronic F-127 is a block copolymer (PEO-PPO-PEO) that gels at low concentrations and can be tuned using other excipients. These experiments will quantify, for the first time, structural changes of concentrated F-127 systems mixed with a control drug and additives under controlled temperature after combined shear and extensional flow as experienced during real bodily injection. Correlating these changes to drug release will allow us to optimise novel injectable pharmaceutical formulations.

Principal Investigator: Professor Tim Gough
Experimenter: Dr Bana Shriky
Local Contact: Dr Najet Mahmoudi

DOI: 10.5286/ISIS.E.RB1800037

ISIS Experiment Number: RB1800037

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Tim Gough et al; (2018): Structure and gelation of poloxamer based hydrogels for injectable drug delivery, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1800037

Data is released under the CC-BY-4.0 license.