ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
How does oxidative damage change peptide membrane insertion?
Abstract: The insertion of peptides and proteins into cell membranes is crucial for the functioning of cells, and also for the functioning of a variety of antibacterial reagents. Cells are continually subject to oxidation events. In this experiment we will use neutron reflection to investigate how oxidative damage changes the interaction between two different, well studied peptides, melittin and protegrin, and cell membrane models of differing composition. The results will help us understand better the factors that influence the interaction of different peptides with cell membranes, and how that interaction is changed by oxidative damage.
Principal Investigator: Dr Katherine Thompson
Experimenter: Mr Emil Gustafsson
Experimenter: Professor Adrian Rennie
Local Contact: Dr Mario Campana
DOI: 10.5286/ISIS.E.RB1810751
ISIS Experiment Number: RB1810751
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.94114868 | SURF | 18 September 2021 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Dr Katherine Thompson et al; (2018): How does oxidative damage change peptide membrane insertion?, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1810751
Data is released under the CC-BY-4.0 license.
