ISIS Neutron and Muon Source Data Journal

Assembly of supramolecular nanotubes into tubisome structures from self-assembled cyclic-peptide polymer conjugates

Abstract: Cyclic peptide-polymer conjugates can readily self-assembly into long nanotubes, and are being extensively studied for biomedical applications. Recently, we have conjugated a hydrophobic chain onto one side of the cyclic peptide (CP), and a hydrophilic chain on the other. Using SANS, we discovered that these structures self-assembled into large Janus-like structures, coined "tubisomes," with a hydrophobic core surrounded by CP-nanotubes and a hydrophilic shell. These make excellent candidates as trans-membrane pores, and drug/gene delivery vehicles. In the proposed study we will look at the pH induced self-assembly of these structures, where the hydrophobic shell consists of a pH-responsive polymer, as changing the pH will induce assemble/disassemble. By studying this closely we can pin down the fundamental parameters needed to control the assembly process to make bespoke structures.

Principal Investigator: Professor Sebastien Perrier
Experimenter: Dr Ed Mansfield
Experimenter: Dr Joaquin Sanchis Martinez
Experimenter: Dr Qiao Song
Local Contact: Dr Robert Dalgliesh
Experimenter: Ms Julia Rho
Experimenter: Mr Sean Heinere Tivini Robert Ellacott

DOI: 10.5286/ISIS.E.RB1820149

ISIS Experiment Number: RB1820149

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
Select the data format above to find out more about it.

Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Sebastien Perrier et al; (2018): Assembly of supramolecular nanotubes into tubisome structures from self-assembled cyclic-peptide polymer conjugates, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1820149

Data is released under the CC-BY-4.0 license.