ISIS Neutron and Muon Source Data Journal

Neutron reflectivity studies of the interaction of Amphotericin B with biomimetic lipid monolayers

Abstract: Bio-surfactants that can be harvested from micro-organisms are of particular interest, because these can potentially be harvested in high yield and at low cost. In this category of bio-surfactants, are the rhamnolipids that are produced by various forms of bacteria. Rhamnolipids not only show very low-toxicity and are bio-degradable, they can now be produced with high efficiency allowing for economical production and industrial scalability. These characteristics, together with their proven anti-fungal activity, makes them very promising candidates for use in manufacture of active drug delivery systems for drugs like amphotericin B. In the studies proposed here, we aim to carry out neutron reflectivity experiments to determine the structure of the AmB-containing monolayers formed at the air-water interface by rhamnolipid(/sterol) with and without AmB.

Principal Investigator: Dr Fabrizia Foglia
Local Contact: Dr Mario Campana
Experimenter: Dr Dave Barlow
Experimenter: Dr Farooq Malik
Experimenter: Dr Delaram Ahmadi

DOI: 10.5286/ISIS.E.RB1820447

ISIS Experiment Number: RB1820447

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Fabrizia Foglia et al; (2018): Neutron reflectivity studies of the interaction of Amphotericin B with biomimetic lipid monolayers, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1820447

Data is released under the CC-BY-4.0 license.