ISIS Neutron and Muon Source Data Journal

Structural Changes in Micellar Self-Assemblies of Amphiphilic Drugs in Aqueous Solutions

Abstract: This study aims the micelle size and shape phase transition investigation for the amphiphilic drugs; adiphenine-HCl (antihistamine), amitriptyline-HCl (antidepressant), and pavatrine (spasmolytic) in aqueous solutions with high concentration solutions to be of particular interest of this study. By understanding the general principles that govern the structural changes of micelle self-assemblies in amphiphilic drug systems with and without ionic variations and especially at high concentrations, drug delivery systems of high drug-loading capacity can be developed. In addition, the interactions between the micelle self-assemblies and other polymer networks (e.g. drug carriers) can be defined, while the drug solubility and release/loading mechanism can be controlled. This allows the structural behaviour of other complicated drugs, like doxorubicin used in cancer therapy, to be interpreted.

Principal Investigator: Dr Christina Efthymiou
Experimenter: Dr Johan Gråsjö
Local Contact: Dr Najet Mahmoudi
Experimenter: Dr Lars Magnus Angantyr Bergström
Experimenter: Professor Per Hansson

DOI: 10.5286/ISIS.E.RB1900031

ISIS Experiment Number: RB1900031

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Christina Efthymiou et al; (2018): Structural Changes in Micellar Self-Assemblies of Amphiphilic Drugs in Aqueous Solutions, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1900031

Data is released under the CC-BY-4.0 license.