ISIS Neutron and Muon Source Data Journal

Effect of monodispersity on core crystallinity, core packing and nanoparticle morphology of self-assembled block-co-polymers

Abstract: The still unreached goal of nanomedicine is to deliver drugs which are only released in the diseased tissue in a controlled fashion. For this, tailorable, reproducible, and highly controlled drug delivery systems are required. Whereas nature uses discrete building blocks, the current status quo in drug delivery is the use of ill-defined polydisperse macromolecules. Synthetic efforts in material science yielded discrete macromolecules which have astonishingly different properties than their polydisperse counterparts. Here the self-assembly of discrete block-co-oligomers in water is compared to their polydisperse counterparts. Gaining structural insight into these systems will help in establishing the effect of monodispersity on size, architecture, core-crystallinity and packing, all important parameters to control stability and the uniformity of drug release.

Principal Investigator: Dr Katja Petkau-Milroy
Local Contact: Dr Robert Dalgliesh
Experimenter: Dr Ilja Voets
Experimenter: Miss Marle Vleugels
Experimenter: Dr Rodrigo Magana Rodriguez

DOI: 10.5286/ISIS.E.RB1869004

ISIS Experiment Number: RB1869004

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Katja Petkau-Milroy et al; (2018): Effect of monodispersity on core crystallinity, core packing and nanoparticle morphology of self-assembled block-co-polymers, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1869004

Data is released under the CC-BY-4.0 license.