ISIS Neutron and Muon Source Data Journal

This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.


Inelastic Neutron Scattering Studies of C-H Bond Activation in Organo-rhodium Anticancer Complexes

Abstract: Cp* ligands are usually considered to be innocent in metallodrugs. However, we observed rapid sequential deuteration of all 15 Cp* methyl protons in RhIII complexes [(η5-Cp*)Rh(N,N)Cl]PF6 (Fig. 1), where Cp* is pentamethylcyclopentadienyl anion and N,N = bipyridyl in aqueous media at ambient temperature. We have discovered that this sequential deuteration proceeds via a substituted fulvene intermediate. This unusual reactivity might contribute towards the anticancer activity of the complexes. We aim to correlate of this unusual reactivity with the cancer cell cytotoxicity. This proposed study will investigate the dynamics of the sequential deuteration using neutron scattering (on TOSCA) to elucidate the distribution of the incorporated deuterium within the Cp* ring at various levels of deuteration.

Principal Investigator: Professor Peter Sadler
Experimenter: Dr Samya Banerjee
Local Contact: Dr Jeff Armstrong

DOI: 10.5286/ISIS.E.RB1810565

ISIS Experiment Number: RB1810565

Part DOI Instrument Public release date Download Link
10.5286/ISIS.E.92919599 TOSCA 08 May 2021 Download

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Peter Sadler et al; (2018): Inelastic Neutron Scattering Studies of C-H Bond Activation in Organo-rhodium Anticancer Complexes, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1810565

Data is released under the CC-BY-4.0 license.



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