ISIS Neutron and Muon Source Data Journal

Investigation of surface conjugation of proteins in lipid membrane using neutron reflectivity

Abstract: Bilayer lipid membranes and their interactions with the integral or peripheral proteins serve as one of the key mechanism in various cellular functions like communication, cell defences, signal transduction etc. In the cell membranes the lipid bilayers acts as filter or switchable gate way, controlling the flow of nutrients into and metabolic wastes out of the cells and organelles. The sensitivity of these lipid molecules in the membranes to local concentration of ions changes dramatically the surface tension, stretching and bending elasticity, viscosity of the membrane and is believed to have key role in cell membrane fluidity or permeability. In this proposal, we will investigate the interaction of flexible or semi-flexible long chain proteins with the lipid monolayer which can help to predict the transport of molecules through cell membrane and the flexibility in shape/size of cells.

Principal Investigator: Dr Mrinmay Kumar Mukhopadhyay
Experimenter: Mr Rajendra Prasad Giri
Local Contact: Dr John Webster
Experimenter: Professor Abhijit Chakrabarti
Experimenter: Professor Milan Sanyal
Experimenter: Mr Arnab Singh
Experimenter: Mr Arnab Singh

DOI: 10.5286/ISIS.E.RB1768022

ISIS Experiment Number: RB1768022

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
Select the data format above to find out more about it.

Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Mrinmay Kumar Mukhopadhyay et al; (2017): Investigation of surface conjugation of proteins in lipid membrane using neutron reflectivity, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1768022

Data is released under the CC-BY-4.0 license.