ISIS Neutron and Muon Source Data Journal

Cubosomes as biosensors: A kinetic study of changes to lattice parameter and particle size

Abstract: Lipid bicontinuous cubic phases are self-assembled three dimensional lattices, consisting of a single periodic bilayer interwoven by two independent water channels. They can be dispersed in aqueous media and coated with a pluronic to form uniform particles, termed cubosomes. The size of the water channel can be tuned by varying the lipid composition. This proposal characterises changes to cubosomes in response to such variations in lipid composition on multiple length scales, i.e. the lattice parameters and overall particle size. Specifically, it will be the first kinetic study using neutron scattering to monitor the online conversion of cubosome lipid compositions as they form highly curved lipid phases. The findings are essential to fundamentally characterise diagnostic assays, under development within our lab for in vivo applications and commercialisation.

Principal Investigator: Dr Hanna Barriga
Experimenter: Dr Derrick Roberts
Experimenter: Professor Molly Stevens
Experimenter: Dr Isaac Pence
Experimenter: Dr Margaret Holme
Local Contact: Dr James Doutch
Experimenter: Miss Valeria Nele

DOI: 10.5286/ISIS.E.RB1810329

ISIS Experiment Number: RB1810329

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Hanna Barriga et al; (2018): Cubosomes as biosensors: A kinetic study of changes to lattice parameter and particle size, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1810329

Data is released under the CC-BY-4.0 license.