ISIS Neutron and Muon Source Data Journal

Electrostatic Interactions between Floating Bilayers and Thiol Coated Interfaces Controls water Gap Thickness

Abstract: Bilayers which float below a self-assembled monolayer (SAM) coated solid support represent one of the most advanced membrane mimetics. Recently (RB 1720155) we assessed the feasibility of depositing floating supported membranes below self-assembled monolayers of (15-Mercaptopentadecyl)-1-aminoethanol (ThiolC15AmideAlcohol). We plan to continue this research by creating eight differing model bilayer systems at the gold/water interface and examining the structures of these biomembrane mimetics using. Each bilayer will be deposited below both pure ThiolC15AmideEthanol SAMs and a mixed 50:50 mixed ThiolC15AmideEthanol and ThiolC15AmideAmine SAMs. We wish to access the relationship between bilayer-SAM electrostatics and water gap distance. From this we aim to determine which sample and SAM conditions are optimal for producing stable floating membranes for a diverse range of lipid species.

Principal Investigator: Dr Luke Clifton
Local Contact: Dr Jos Cooper
Experimenter: Dr Martynas Gavutis
Experimenter: Dr Nicolò Paracini
Local Contact: Dr Nina-Juliane Steinke
Experimenter: Professor Jeremy Lakey [Deactivated] [Deactivated]

DOI: 10.5286/ISIS.E.RB1820034

ISIS Experiment Number: RB1820034

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Luke Clifton et al; (2018): Electrostatic Interactions between Floating Bilayers and Thiol Coated Interfaces Controls water Gap Thickness, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1820034

Data is released under the CC-BY-4.0 license.