ISIS Neutron and Muon Source Data Journal

Structure of Confined Albumin Layers

Abstract: In the context of a project in collaboration with ISIS that focuses on structural studies under mechanical confinement, with a specific focus on biological lubricants, the applicants performed preliminary neutron reflectometry experiments at D17 (ILL) on the hydration of confined layers of mucins, the long glycoproteins that account for most of the material in biological fluids such as mucus and saliva. These experiments indicated that mucins can hold large amounts of water up to pressures as high as 5 bar. However, further controls are needed to support this interpretation. Here, we apply for investigating how the data obtained for mucins differ from that of a compact globular protein i.e., albumin. This will confirm that our previous results do indeed originate from the long unstructured nature of mucins and not by an instrumental artefact.

Principal Investigator: Dr Javier Sotres
Experimenter: Mr Ashton Stone
Experimenter: Miss Hannah Boyd
Experimenter: Professor Rob Richardson
Experimenter: Dr Rob Barker
Experimenter: Dr Juan Francisco Gonzalez
Experimenter: Dr Stuart Prescott
Experimenter: Dr Rebecca Welbourn

DOI: 10.5286/ISIS.E.RB1720422

ISIS Experiment Number: RB1720422

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Javier Sotres et al; (2018): Structure of Confined Albumin Layers, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1720422

Data is released under the CC-BY-4.0 license.