ISIS Neutron and Muon Source Data Journal

Neutron reflectivity studies of the interaction between a novel antimicrobial agent and biomimetic lipid monolayers

Abstract: A Unilever proprietary technology has been shown to inhibit biofilm growth and development, and is also found to possess antimicrobial activity, effective both as a broad-spectrum antibacterial and as an antifungal agent. This is unusual and requires both specific and holistic understanding of the agent’s mode of action at a molecular level. In the studies proposed here (performed using the technique of neutron reflectivity), we aim to determine the effect of this potential new drug on model fungal, bacterial and mammalian cell membranes. We hope then to elucidate the key common factors which render the technology effective in controlling biofilm formation as well as exploring the its impact on different infective organisms.

Principal Investigator: Dr Dave Barlow
Experimenter: Mr Xing Chen
Experimenter: Dr Delaram Ahmadi
Experimenter: Professor Jayne Lawrence
Experimenter: Dr Farooq Malik
Experimenter: Dr Ian Tucker
Local Contact: Dr Mario Campana
Experimenter: Dr Fabrizia Foglia

DOI: 10.5286/ISIS.E.RB1820319

ISIS Experiment Number: RB1820319

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Dave Barlow et al; (2018): Neutron reflectivity studies of the interaction between a novel antimicrobial agent and biomimetic lipid monolayers, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1820319

Data is released under the CC-BY-4.0 license.