ISIS Neutron and Muon Source Data Journal

PROBING DRUG PHARMACODYNAMICS BY INS - THE EFFECT OF CISPLATIN-LIKE ANTICANCER DRUGS ON DNA

Abstract: Cancer is a growing health problem worldwide, and thus the development of effective chemotherapeutic approaches is crucial for improving human health. Much effort has been put into the design of metal-based drugs, particularly Pt(II) and Pd(II) polyamine chelates acting through unconventional interactions with DNA. These agents have been extensively investigated by the authors in the last decade.Following previous QENS experiments that revealed a clear effect of these metal-based anticancer drugs on the dynamical behaviour of DNA through an impact on its hydration layer (RB1710167, paper under preparation), the present INS experiment aims to monitor drug-prompted structural changes in the nucleic acid as well as in its hydration shell. This is an innovative way of tackling a drug´s pharmacodynamics at a molecular level, water being suggested as a secondary pharmacological target.

Principal Investigator: Dr Maria Paula Marques
Experimenter: Dr Ana Carvalho
Experimenter: Dr Ana Batista de Carvalho
Experimenter: Dr Svemir Rudic
Experimenter: Miss Adriana Mamede
Experimenter: Dr Luis Alberto Batista de Carvalho

DOI: 10.5286/ISIS.E.RB1820103

ISIS Experiment Number: RB1820103

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Maria Paula Marques et al; (2018): PROBING DRUG PHARMACODYNAMICS BY INS - THE EFFECT OF CISPLATIN-LIKE ANTICANCER DRUGS ON DNA, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1820103