ISIS Neutron and Muon Source Data Journal

Small-angle neutron scattering study of human growth hormone-surfactant complexes

Abstract: Liquid pharmaceutical formulations are commonly comprised of proteins and surfactants, which interact in solution in order to provide an increase in system stability. Although these systems have been significantly investigated in the last few years, there is a lack of consensus concerning the interaction mechanism between proteins and surfactants. We believe that contrast variation small-angle neutron scattering can provide specific information about these systems and contribute to resolving the puzzle. In this experiment we aim to elucidate the interactions between human growth hormone and a prototypical anionic amphiphiles at room temperature. The use of isotope labelling and contrast matching will provide detailed information about individual parts of the system, which will then be co-refined in order to provide structural information of the protein-surfactant complexes as a whole.

Principal Investigator: Dr Judith Houston
Experimenter: Dr Adrian Sanchez-Fernandez
Local Contact: Dr Sarah Rogers

DOI: 10.5286/ISIS.E.RB1900057

ISIS Experiment Number: RB1900057

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Judith Houston et al; (2018): Small-angle neutron scattering study of human growth hormone-surfactant complexes, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1900057

Data is released under the CC-BY-4.0 license.