ISIS Neutron and Muon Source Data Journal

The mechanism of lipid transport in Gram-negative bacteria

Abstract: The bacterial cell envelope is one of the best targets in antimicrobial development. This proposal focuses on understanding how lipids move between the membranes of the gram-negative cell envelope as understanding this pathway could lead to inhibiting it and thus the development of new antimicrobials. This proposal focuses on understanding how lipids move between the membranes of the gram-negative cell envelope. Until recently how lipids were transported between the membranes of the cell envelope was unknown, however, the Mla pathway, has been identified that provides the first evidence of a lipid transport pathway. How this pathway functions remains unknown. The aim of this proposal is to tackle these issues. Neutron reflectometry provides the ideal tool for monitoring the movement of lipids to and from the membrane and provide vital information about how the Mla pathway function.

Principal Investigator: Dr Tim Knowles
Experimenter: Dr Mark Jeeves
Local Contact: Dr Rebecca Welbourn
Experimenter: Dr Stephen Hall
Experimenter: Dr Luke Clifton
Experimenter: Dr Gareth Hughes
Experimenter: Mr stephen bethell
Experimenter: Dr Luke Alderwick
Experimenter: Miss Rebecca Parr

DOI: 10.5286/ISIS.E.RB1720492

ISIS Experiment Number: RB1720492

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Tim Knowles et al; (2017): The mechanism of lipid transport in Gram-negative bacteria, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1720492

Data is released under the CC-BY-4.0 license.