ISIS Neutron and Muon Source Data Journal

Role of apolipoprotein E variant on HDL interactions at model cell membranes

Abstract: Atherosclerosis is the leading cause of death in western society, its consequences such as strokes and heart attacks arise from the build-up of plaques of fat which accumulate in the artery walls. Lipoprotein particles were shown to play a role in this disease, however they role is still not fully understood. For example, the specific apolipoprotein variants in lipoproteins can give either a protective or a detrimental effect. Understanding these developments and determining the importance of the lipoprotein particle composition in terms of both apolipoprotein variant and lipid cargo is fundamental in the diagnosis and treatment of the disease as today clinical lipid profiling fails to properly predict the risk to develop this disease. The goal of this project is to undertand the role of apolipoprotein variant on lipid dynamics at model cellular membranes by neutron reflection.

Principal Investigator: Professor Marité Cárdenas Gómez
Experimenter: Professor Trevor Forsyth
Experimenter: Miss Sarah Waldie
Experimenter: Dr Michael Haertlein
Local Contact: Dr Maxmilian Skoda
Experimenter: Dr Selma Maric
Experimenter: Dr Tania Lind

DOI: 10.5286/ISIS.E.RB1720514

ISIS Experiment Number: RB1720514

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Marité Cárdenas Gómez et al; (2018): Role of apolipoprotein E variant on HDL interactions at model cell membranes, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1720514

Data is released under the CC-BY-4.0 license.