ISIS Neutron and Muon Source Data Journal

Solubilisation of steroidal drug in dodecyl sulphate micelles: effect of anion

Abstract: An number of potential drugs are extremely water insoluble, limiting their commercialisation as medicines. Solubilisation of drug in surfactant micelles is a means of increasing the apparent aqueous solubility of a drug and ensuring exploitation as a medicine. Micelles formed by the anionic surfactant, sodium dodecyl sulphate, are an excellent solubiliser of poorly soluble steroidal drugs (testosterone enanthate, 4-cholesten-3-one and adrenosterone). However, changing the anion grealty influences solubilisation with lithium increasing and ammonium decreasing solubilisation in the doecyl sulphate micelle. Using SANS with contrast variation we aim to probe the effect of counterion on the structure of the surfactant micelle in solution, and the way in which the drug is solubilised, thereby aiding in the rationale design and selection of surfactants to optimise drug solubilisation.

Principal Investigator: Professor Jayne Lawrence
Local Contact: Dr Steve King
Experimenter: Dr Peixun Li
Experimenter: Mr Xing Chen
Experimenter: Miss yanan shao
Experimenter: Ms Demi Pink
Experimenter: Dr Dave Barlow

DOI: 10.5286/ISIS.E.RB1720386

ISIS Experiment Number: RB1720386

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Jayne Lawrence et al; (2017): Solubilisation of steroidal drug in dodecyl sulphate micelles: effect of anion , STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1720386

Data is released under the CC-BY-4.0 license.