ISIS Neutron and Muon Source Data Journal

Bacterial membrane disruption by layered double hydroxide particles

Abstract: Layered double hydroxides (LDHs) have recently been identified as interesting drug delivery vehicles due to their ability to intercalate guest molecules. Additionally, LDHs display membrane-disrupting capabilities and antimicrobial effects on their own. However, understanding the relation between membrane interactions and antimicrobial effects is critical for the successful use of LDH as antimicrobial agents and as carriers of guest molecules such as antimicrobial peptides. In order to elucidate the membrane disruption mechanism of LDHs, we propose to investigate the effect of particle size by using three LDH particles with differing aspect ratios (42, 104, and 208 nm). Each particle will be measured with both bacteria-mimicking and mammalian-mimicking lipid membranes that have been contrast matched to D2O such that the only small angle scattering will be from the LDH particles.

Principal Investigator: Professor Martin Malmsten
Local Contact: Dr Najet Mahmoudi
Experimenter: Dr Sara Malekkhaiat Häffner
Local Contact: Dr Sarah Rogers
Experimenter: Dr Kathryn Browning
Experimenter: Mr Bruno Luigi Carlo Borro

DOI: 10.5286/ISIS.E.RB1700051

ISIS Experiment Number: RB1700051

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Martin Malmsten et al; (2017): Bacterial membrane disruption by layered double hydroxide particles, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1700051

Data is released under the CC-BY-4.0 license.