ISIS Neutron and Muon Source Data Journal

pH-control of swelling and charge neutralization of thin hydrogel films

Abstract: Hydrogels are widely used in biomaterials science, much due to excellent protein resistance, and physicochemical properties similar to biological tissue. Charge neutrality is essential for protein resistance, and can be achieved with uncharged hydrophilic polymers, but also zwitterionic and other charge-compensated materials are effective in this respect. The presence of a large number of ionizable groups facilitate strong ionic hydration, reducing protein adsorption. However, the neutrality is pH-sensitive, and antifouling properties might not be retained if the pH is changed. We exploit this pH-sensitivity to develop coatings with pH-tuneable protein resistance, formed from layers of oppositely charged polymers. However, our understanding of the charge-neutralization, and the precise relation to polymer composition and intermixing is limited, and will be addressed in this study.

Principal Investigator: Dr Thomas Ederth
Experimenter: Dr Bela Nagy
Local Contact: Dr Arwel Hughes

DOI: 10.5286/ISIS.E.RB1810538

ISIS Experiment Number: RB1810538

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Thomas Ederth et al; (2018): pH-control of swelling and charge neutralization of thin hydrogel films, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1810538

Data is released under the CC-BY-4.0 license.