ISIS Neutron and Muon Source Data Journal

Membrane-stacking Properties of Mutant Myelin Proteins

Abstract: Myelin is the multilamellar structure that ensheaths axons and accelerates nervous impulses in the nervous system. The fine structure of myelin remains to be further characterized on the biomolecular scale. There are many myelin proteins that contribute to myelin membrane stacking and are involved in demyelinating diseases. We propose an experiment at the INTERneutron reflectometer, where the properties of these proteins can be investigated on supported stacked lipid bilayers. The proteins are disease mutant variants found in Charcot-Marie-Tooth neuropathy patients, . We started characterizing these proteins on INTER earlier this year, and the methods we use have been optimized before on SURF & D17 (ILL) reflectometers. We want to understand the impact of the mutations on the structural function of the protein. We therefore request an experiment of 5 days on the INTER reflectometer.

Principal Investigator: Dr Petri Kursula
Experimenter: Miss Irantzu Yoldi
Experimenter: Dr Rob Barker
Experimenter: Dr Arne Raasakka
Local Contact: Dr Mario Campana

DOI: 10.5286/ISIS.E.RB1810799

ISIS Experiment Number: RB1810799

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Petri Kursula et al; (2018): Membrane-stacking Properties of Mutant Myelin Proteins, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1810799

Data is released under the CC-BY-4.0 license.