ISIS Neutron and Muon Source Data Journal

Assessing the interactions of cyclic peptide-polymer conjugates with a lipid bilayer

Abstract: Cyclic peptide-polymer nanotubes can readily self-assembly into long nanotubes, and are being extensively studied for drug delivery applications. As such, understanding how these systems behave when interacting with a cell membrane is of critical importance. Recently, we have shown that different polymer-peptide compositions have very different cell-uptake properties, whilst remaining non-toxic. Here we wish to study how different conjugates interact with a lipid bilayer and understand the kinetics and mechanisms of these interactions. Using this information we can develop a more novel range of cyclic peptide nanotubes with the goal of designing systems able to readily assemble and disassembly in the cell membrane without any adverse toxicity effects.

Principal Investigator: Professor Sebastien Perrier
Experimenter: Dr Carlos Sanchez-Cano
Experimenter: Mr Sean Heinere Tivini Robert Ellacott
Experimenter: Dr Ed Mansfield
Local Contact: Dr Mario Campana
Experimenter: Dr Raoul Peltier
Experimenter: Miss Agnes Kuroki

DOI: 10.5286/ISIS.E.RB1810196

ISIS Experiment Number: RB1810196

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Sebastien Perrier et al; (2018): Assessing the interactions of cyclic peptide-polymer conjugates with a lipid bilayer, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1810196

Data is released under the CC-BY-4.0 license.