ISIS Neutron and Muon Source Data Journal

Understanding the interaction between antimicrobial peptide-loaded lipid particles with bacteria mimicking membranes

Abstract: The number of antibiotic-resistant bacteria is increasing worldwide, and the demand for novel antimicrobials is constantly growing. Antimicrobial peptides (AMPs) could be an important part of future treatment strategies of various bacterial infection diseases. However, AMPs have relatively low stability, because of proteolytic degradation. As a consequence, carrier systems protecting the AMPs are greatly needed, to achieve efficient treatments. Dispersions of lipid-based liquid crystalline nanoparticles (cubosomes) are biocompatible drug delivery vehicles, well suited for delivery and protection of AMPs, due to their ability to encapsulate amphipathic molecules. However, the bacterial membrane disruptive properties of the AMP-loaded cubosomes remains unclear, but can be studied using neutron reflectivity.

Principal Investigator: Professor Martin Andersson
Experimenter: Miss Randi Nordström
Experimenter: Ms Liv Sofia Elinor Damgaard
Experimenter: Dr Kathryn Browning
Experimenter: Mr Lukas Boge
Local Contact: Dr Arwel Hughes

DOI: 10.5286/ISIS.E.RB1810031

ISIS Experiment Number: RB1810031

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Martin Andersson et al; (2018): Understanding the interaction between antimicrobial peptide-loaded lipid particles with bacteria mimicking membranes, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1810031

Data is released under the CC-BY-4.0 license.